Tam sim no, muaj txog 81 hom tshuaj tiv thaiv qog nqaij hlav feem ntau siv hauv chaw kho mob.1. Cov tshuaj tiv thaiv qog nqaij hlav raug cais raws li lawv qhov chaw thiab cov txheej txheem ntawm kev ua.Feem ntau muab faib ua cov tshuaj alkylating, antimetabolites, tshuaj tua kab mob, nroj tsuag, tshuaj hormones thiab lwm yam tshuaj.Lwm cov tshuaj muaj xws li platinum, asparaginase, tshuaj kho mob, thiab lwm yam, tsis suav nrog cov tshuaj lom neeg thiab cov tshuaj kho noob.Qhov kev faib tawm no tsis tuaj yeem piav qhia txog kev txhim kho tam sim no ntawm cov tshuaj tiv thaiv qog.Qhov thib ob, lwm qhov kev faib tawm yog nyob ntawm cov hom phiaj molecular ntawm cov tshuaj, uas tau muab faib ua ntau pawg.Thawj qeb yog cov tshuaj uas ua rau cov qauv tshuaj ntawm DNA, xws li alkylating lossis platinum compounds.Cov qeb thib ob yog cov tshuaj uas cuam tshuam rau nucleic acid synthesis, xws li cov tshuaj tiv thaiv metabolite.Cov qeb thib peb yog cov tshuaj uas ua rau cov qauv DNA, cuam tshuam rau kev hloov pauv thiab inhibition ntawm DNA, thiab inhibits RNA synthesis los ntawm kev cia siab rau RNA polymerase.Cov qeb plaub yog cov tshuaj uas cuam tshuam rau kev tsim cov protein, xws li paclitaxel, vinblastine thiab lwm yam.Cov qeb kawg yog lwm hom tshuaj, xws li cov tshuaj hormones, aspartic acid, cov tshuaj tiv thaiv kev kho mob, thiab lwm yam, tab sis tam sim no cov tshuaj tiv thaiv qog nqaij hlav loj hlob sai, thiab cov pawg saum toj no tsis tuaj yeem sau cov tshuaj uas twb muaj lawm thiab cov tshuaj uas hais txog. nkag mus hauv tsev kho mob..“

Tam sim no, muaj ntau yam tshuaj tiv thaiv qog noj ntshav hauv kev kho mob.Piv txwv li,oxaliplatin, tshuaj fluorouracil, thiab irinotecan tuaj yeem siv rau cov qog nqaij hlav hauv plab.Cov neeg mob qog nqaij hlav plab tuaj yeem kho nrog tshuaj xws licisplatinthiabpaclitaxel.Feem ntau, cov qog nqaij hlav sib txawv xaiv cov tshuaj sib txawv.Tsis tas li ntawd, cov neeg mob qog noj ntshav kuj tuaj yeem kho nrog cov tshuaj tiv thaiv molecular, xws li erlotinib, osimertinib, cetuximab thiab lwm yam tshuaj.

Cov tshuaj tiv thaiv qog nqaij hlav uas ua rau CIPN suav nrogPaclitaxel, Platinum , Vinblastine ,MethotrexateFluorouracil, Ifosfamide,CytarabineFludarabine, Thalidomide,Bortimiazolethiab lwm yam.

Paclitaxel siv cov paj hlwb loj hlob los txo lossis thim rov qab neurotoxicity;cisplatin siv txo glutathione thiab amifostine los tiv thaiv neuropathy los ntawm nws;oxaliplatin tsis hu rau qhov txias stimulation thaum siv los tiv thaiv kev mob khaub thuas los ntawm kev cuam tshuam cov hlab ntsha peripheral Stimulation, kev siv cov calcium-magnesium sib tov tuaj yeem txo qhov tshwm sim thiab siv cov tsos mob ntawm cov mob neurotoxicity, thiab ncua qhov tshwm sim ntawm cov kab mob neuropathy;ifosfamide tuaj yeem xaiv methylene xiav los tiv thaiv neurotoxicity;siv thiamine rau fluorouracil tuaj yeem tiv thaiv cov paj hlwb Toxic.