Cov kab mob autoimmune, uas muaj ntau hom thiab feem ntau yog cov kab mob refractory thiab mob hnyav, yog ib qho ntawm cov lus qhia tseem ceeb ntawm kev txhim kho tshuaj tam sim no.JAK-STAT yog ib qho ntawm ob peb txoj hauv kev immunomodulatory uas tau raug pov thawj, tshwj xeeb tshaj yog JAK inhibitors.Ntau yam tshuaj,xws li tofacitinib, tau ua lag luam thoob ntiaj teb.

Lub hom phiaj JAK tau tsim muaj tsawg dua 20 xyoo, tab sis tam sim no ze li ntawm 7 ntau yam tau pom zoo rau kev lag luam.Cov lus qhia feem ntau yog cov qog nqaij hlav thiab cov kab mob tiv thaiv tus kheej, thiab cov kev qhia ua kom zoo ntxiv yog cov pob txha pob txha fibrosis thiab mob caj dab rheumatoid.Cov hauv qab no tsom rau thawj JAK inhibitor (tofacitinib) rau kev kho mob rheumatoid mob caj dab.

Tofacitinib yog lub qhov ncauj me me molecule JAK inhibitor tsim los ntawm Pfizer.Nws muaj kev xaiv zoo JAK.Thaum Lub Kaum Ib Hlis 2012, US FDA tau pom zoo tofacitinib citrate rau kev kho mob ntawm methotrexate tsis txaus lossis tsis txaus siab rau kev kho mob.Cov khoom no yog thawj JAK inhibitor pom zoo los ntawm FDA rau kev kho mob rheumatoid mob caj dab.Tam sim no, ntxiv rau cov ntawv pom zoo, tofacitinib tseem raug kuaj xyuas nws cov txiaj ntsig hauv ankylosing spondylitis, atopic dermatitis, keratoconjunctivitis sicca thiab Crohn's disease.Hais txog kev muag khoom thoob ntiaj teb, kev muag khoom txhua xyoo ntawm tofacitinib hauv 2017 tau ntau dua US $ 1 billion, thiab kev muag khoom txhua xyoo hauv 2019 tau mus txog US $ 2.242 billion.

Cov kev sib txawv ntawm cov hluavtaws sib txawv yuav muaj kev cuam tshuam zoo rau cov txiaj ntsig thiab qhov zoo ntawm APIs.Peb synthesis ntawm tofacitinib citrate zam txoj kev patented.Txoj kev hluavtaws xav tau cov khoom siv qis qis, cov khoom lag luam siab, ib qho impurities thiab purity tuaj yeem tswj tau hauv qhov tsim nyog, lossis tuaj yeem hloov kho los ntawm cov neeg siv khoom.Yog li pab kom peb muaj qhov zoo dua ntawm kev ua lag luam.Tam sim no peb lub peev xwm tuaj yeem yog 50kg ib hlis, thiab tofacitinib citrate twb xa tawm mus rau Tebchaws Meskas, Mexico, Franch, Bangladesh, thiab lwm yam.